Summary of Molécula de selênio desenvolvida pelos pesquisadores é mais potente e causa menos efeitos colaterais

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Researchers at the Celen Laboratory in the Federal Fluminense University in Brazil are developing new selenium-containing molecules with the goal of combating tuberculosis and antibiotic-resistant bacteria. Current treatments for tuberculosis are lengthy and toxic, and the team is focused on creating more potent selenium molecules to improve patient compliance and combat drug-resistant strains. The researchers identified three promising molecules that effectively kill the tuberculosis-causing bacterium and resistant bacteria without harming healthy cells. The challenges in purifying the molecules required resilience and persistence, but ultimately led to the successful production of the molecules. The team presented their research at a major selenium congress and received international recognition. The project was a significant accomplishment for the researchers, who were proud to contribute to the fight against tuberculosis, a disease often overlooked by the public.

• 00:00:00 In this section of the YouTube video titled "Molécule of selenium developed by researchers is more potent and causes fewer side effects", researchers at the Celen Laboratory in the Federal Fluminense University in Brazil discuss their objective of developing molecules containing the essential micronutrient selenium to combat tuberculosis and antibiotic-resistant bacteria. Current treatments for tuberculosis are lengthy and toxic, lasting up to two years, and many patients discontinue the treatment, which can be fatal, particularly for vulnerable populations. To address this, the lab is developing more potent selenium-containing molecules that can combat resistant bacteria. Previous studies in Brazil have demonstrated that longer treatment times increase patient compliance, making the development of a more effective and less toxic tuberculosis treatment crucial. The team focused on the micronutrient selenium and the vitamin K, combining them to create a new molecule with potential applications for tuberculosis treatment. After extensive research, synthesis, purification, and characterization, the researchers identified three promising molecules that effectively killed the tuberculosis-causing bacterium and resistant bacteria without harming healthy cells. The challenges in purifying the molecules required resilience and persistence, but ultimately led to the successful production of the molecules, which tested positively for tuberculosis treatment. The biggest challenge for the researcher when he started at the Celene Laboratory was his first experience in organic synthesis, involving numerous glassware and serials, but his determination and hard work paid off with the successful creation of the desired molecule.
• 00:05:00 In this section, a researcher shares her experience working on a groundbreaking and challenging project involving the development of a new selenium molecule. The project received recognition both in Brazil and internationally, including at a major selenium congress where it was presented and won. The researcher's participation in the project sparked her interest in chemistry and the ability to create something new and applicable. The recognition of their work from the academic community and the general public who expressed interest in their research against tuberculosis was a source of great pride for the team. Despite tuberculosis being considered a forgotten disease, the public was eager to learn more, making this recognition a fantastic accomplishment for the researchers.