Summary of Transitioning Organic Synthesis from Organic Solvents to Water

00:00:00 - 00:45:00

This video discusses the transition from traditional organic synthesis using organic solvents to water-based organic synthesis. The presenter argues that water is a more efficient solvent for organic reactions, and that this transition can result in a more environmentally friendly process.

• 00:00:00 The speaker of this video, Bruce Lipschitz, will discuss how his group has developed a new method for transitioning organic synthesis from organic solvents to water. This new method, called "designer surfactants," enables key transition metal catalyzed cross couplings and other related reactions to be carried out in water most often at room temperature.
• 00:05:00 The video discusses the transition from organic solvents to water as a way to improve organic synthesis. The author argues that water is the most common denominator in this transition, but that we need to create a new world in order to take advantage of its properties. In traditional organic synthesis, soap is a common tool used to help mix oil and water. However, synthetic chemists need their own surfactants in order to do sophisticated organic synthesis. Second-generation surfactants are designed to be as similar to soap as possible, but the author argues that they are actually very different. Third-generation surfactants, called "nocks", are designed to be more versatile and healthier than traditional surfactants.
• 00:10:00 This video provides a brief overview of the benefits of transitioning organic synthesis from organic solvents to water. The main points made are that water is a much more efficient solvent for organic reactions, that particle size and shape are important factors in achieving successful reactions, and that recycling is important in green chemistry.
• 00:15:00 Water can be used in organic synthesis instead of organic solvents, resulting in a decreased amount of waste. This is especially important when making carbon-nitrogen bonds, as it allows for a more efficient process. Additionally, this new chemistry can be used to create carbon-oxygen bonds in asymmetric series.
• 00:20:00 This video explains how transitioning organic synthesis from organic solvents to water can result in a more environmentally friendly process. The carbon-carbon bond forming reactions that are also used for making olefins using olefin metathesis are also applied to making Negishi cross couplings in water. This chemistry is virtually tolerant of all functionality, making it a suitable choice for difficult reactions.
• 00:25:00 The video discusses the benefits of water as an organic synthesis solvent, as well as the challenges of treating water after organic synthesis reactions. The author argues that the advances made in water-based organic synthesis are a major step forward, and that eventually all organic waste will be turned into water.
• 00:30:00 The presenter discusses why organic synthesis using water is a potential alternative to traditional organic solvents, and provides a few examples of how water can be used in organic synthesis.
• 00:35:00 Water can be used in place of organic solvents in many organic synthesis reactions, potentially resulting in a lower Environmental Impact.
• 00:40:00 This video discusses the transition from using organic solvents to water for organic synthesis, and how Sigma Aldrich and Sabir Kurai are helping to make this transition easier. The presenter notes that while water-based organic synthesis is possible, it is challenging to achieve desired product sizes and concentrations without introducing water-soluble impurities. He also discusses how hydrophilic/lipophilic balance and minimizing water content can help to optimize product quality and yield.
• 00:45:00 This video provides a presentation on organic synthesis, discussing the importance of using water as a solvent, and introducing the concept of micellar catalysis. The presenter notes that people can design their own solvents, and recommends thinking outside the box when designing reactions and using appropriate reaction media.