Summary of Pharmacokinetics 5 - Excretion

00:00:00 - 00:05:00

The video discusses how drugs are eliminated from the body, with a focus on how zero order kinetics can lead to an easy overdose. It uses ethanol as an example of a drug with zero order kinetics, and explains how the elimination pattern will follow first-order kinetics once the enzyme is no longer saturated.

• 00:00:00 This tutorial discusses the excretion of drugs. The two main ways in which the body excretes drugs are via the hepatic biliary system and the kidneys. The clearance of a drug is the concentration of a drug in the urine times the rate at which the urine is being produced divided by the concentration of drug in the plasma.
• 00:05:00 This video discusses the pharmacokinetics of drugs, which is the study of how drugs are taken up and eliminated from the body. In particular, it discusses how zero order kinetics (drugs with zero kinetics) can lead to an easy overdose because the rate of excretion doesn't increase with increasing dose. Ethanol is an example of a drug with zero order kinetics, and the elimination pattern will follow first-order kinetics once the enzyme is no longer saturated.