Summary of The Microbes Upon Us: How the Cutaneous Microbiome Promotes Skin Health

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The role of the cutaneous microbiome in promoting skin health is discussed in the video. The skin microbiome is composed of different bacteria that help to keep the skin healthy. The composition of the skin microbiome changes with age and during puberty. The video discusses how the gut microbiome can impact skin health, specifically in relation to cancer.

  • 00:00:00 Tiffany Schmidt, an associate professor of dermatology at the University of California, San Francisco, will speak about the role of the cutaneous microbiome in promoting skin health. She will discuss the cellular and molecular mechanisms that mediate interactions between bacteria and the developing immune response, and discuss the potential therapeutic implications of her research.
  • 00:05:00 The skin microbiome is composed of millions of bacterial cells, and the immune cells present in the skin work in close proximity to one another to promote skin health. The skin microbiome is stable over time, and individual skin microbiomes are unique. Hand washing helps to keep the skin microbiome healthy.
  • 00:10:00 The skin microbiome is unique to individuals and is stable over time. The microbiota is curated for the skin microbiome according to location, with different bacteria present depending on the location. This is due to the different environment and chemical composition of the skin.
  • 00:15:00 The cutaneous microbiome plays an important role in promoting skin health, and different body sites have different microbial compositions. The microbiome is dynamic and changes throughout the lifespan, and knowledge about its organization and growth is important for understanding skin health.
  • 00:20:00 The cutaneous microbiome promotes skin health by helping to keep pathogen levels in check and promoting the growth of healthy bacteria.
  • 00:25:00 The skin microbiome helps tune up the skin's antimicrobial peptides, has a deeper adjuvant function, and helps wound healing. The absence of healthy skin bacteria can lead to susceptibility to skin parasites and decreased immune function. Adding back one healthy skin bacteria to mice that were challenged with a skin parasite restored their susceptibility to the parasite.
  • 00:30:00 The video discusses the role of the cutaneous microbiome in promoting skin health. The skin barrier is composed of dead skin cells and fatty mortar, and bacteria living on the skin produce molecules that help form the barrier. The video cites research that suggests a compromised skin barrier can lead to inflammation. The video discusses how the cutaneous microbiome helps to keep the peace between the immune cells and the bacteria, and how this helps to maintain skin health.
  • 00:35:00 The cutaneous microbiome is important for skin health and helps to prevent inflammation. The skin microbiome changes with age and there is a special window of development when the immune system is less reactive to bacteria. The microbiome is influenced by hair follicles and the presence or absence of these follicles can influence the arrival of Treg cells.
  • 00:40:00 The skin microbiome has been shown to play a role in skin health, and during disease flares, the microbiome can increase and peak in early life and then reduce in adulthood. The microbiome can also help deliver one healthy bacteria, which can have multiple positive effects on the skin, including reducing inflammation and improving acne.
  • 00:45:00 The video discusses the relationship between the skin microbiome and skin health, highlighting that while acne may be caused by the presence of certain strains of P. acnes, the microbiome itself is not necessarily responsible for causing acne. The video also discusses how gut inflammation, which can be caused by a bad microbiome-immune system relationship, can lead to skin inflammation and other conditions. Finally, the video discusses how the gut microbiome may be used to treat certain forms of skin cancer.
  • 00:50:00 The video discusses how the gut microbiome can impact skin health, specifically in relation to cancer. It shows how changes in the gut microbiome can lead to changes in the immune response, which can contribute to the development and progression of cancer. The video also discusses how microbiome research is being used to develop new cancer treatments that are more effective and tolerable.
  • 00:55:00 The skin microbiome is a highly specialized community of bacteria that helps protect against skin pathogens. The composition of the skin microbiome changes with age and during puberty, and sexual attraction may be due to the composition of the skin microbiome. Sweat glands and sexual attraction are both influenced by the microbiome.

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The cutaneous microbiome refers to the microorganisms that reside on the skin. This microbiome can play a role in the development of eczema and other skin conditions. Topical steroids may have less of an impact on the skin microbiome than on the immune system.

  • 01:00:00 The cutaneous microbiome is a complex community of microorganisms that resides on and interacts with the skin. This microbiome can play a role in the development of eczema, and hormonal changes during puberty may affect the skin microbiome. However, topical steroids likely have less of an impact on the skin microbiome than on the immune system.
  • 01:05:00 The skin microbe plays an important role in promoting skin health, and overuse of hand sanitizers can be harmful. There is a window of life during which the skin microbiome is preferentially established, and children are more malleable in their immune system than adults.
  • 01:10:00 The cutaneous microbiome has increased significance and importance due to its role in promoting skin health. Antimicrobial use, breastfeeding, and early life diet can influence the microbiome, which can lead to skin dysregulation and disease. Daily bathing is not necessary, as the microbiome will be restored after one shower.
  • 01:15:00 The cutaneous microbiome plays an important role in promoting skin health, and sunburn can temporarily change the microbiome. There is currently little evidence supporting the use of probiotics for skin conditions.

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