The Radical Honesty Podcast features conversations between Brad Blanton and Tony Shawcross discussing the toxic effects of withholding information in human interactions and how Radical Honesty can counter this by promoting truthful communication. They discuss how the culture of withholding information manifests in politics, personal relationships, and social lives, creating a poisonous environment. The speakers argue that people need to stop speaking with a forked tongue and admit to their good and bad actions. They stress the importance of non-withholding and how it can prevent poison from being exchanged in relationships. Additionally, the speakers call for a new way of seeing and doing things, one that is based on collaboration instead of domination, to help reduce the poisonous effects of our current social systems.